Shifts, Aneuploidy, and Loss of Heterozygosity Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy
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چکیده
, the Etiologic Agents of Cryptococcosis gattii Cryptococcus and Cryptococcus neoformans Doering, et al.
منابع مشابه
Fungal Biofilms, Drug Resistance, and Recurrent Infection Subject Collection Human Fungal Pathogens Loss of Heterozygosity Diversity: Whole Ploidy Shifts, Aneuploidy, and Rapid Mechanisms for Generating Genome
Loss of Heterozygosity Diversity: Whole Ploidy Shifts, Aneuploidy, and Rapid Mechanisms for Generating Genome Richard J. Bennett, Anja Forche and Judith Berman Infection Fungal Biofilms, Drug Resistance, and Recurrent Andes Jigar V. Desai, Aaron P. Mitchell and David R. Pathogenic Species Complex Candida The Siobhán A. Turner and Geraldine Butler Metabolism in Fungal Pathogenesis et al. Iuliana...
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Rapid responses to acute stresses are essential for stress survival and are critical to the ability of fungal pathogens to adapt to new environments or hosts. The rapid emergence of drug resistance is used as a model for how fungi adapt and survive stress conditions that inhibit the growth of progenitor cells. Aneuploidy and loss of heterozygosity (LOH), which are large-scale genome shifts invo...
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The opportunistic pathogen Candida albicans has a large repertoire of mechanisms to generate genetic and phenotypic diversity despite the lack of meiosis in its life cycle. Its parasexual cycle enables shifts in ploidy, which in turn facilitate recombination, aneuploidy, and homozygosis of whole chromosomes to fuel rapid adaptation. Here we show that the tetraploid state potentiates ploidy vari...
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The opportunistic pathogen Candida albicans has a large repertoire of mechanisms to generate genetic and phenotypic diversity despite the lack of meiosis in its life cycle. Its parasexual cycle enables shifts in ploidy, which in turn facilitate recombination, aneuploidy, and homozygosis of whole chromosomes to fuel rapid adaptation. Here we show that the tetraploid state potentiates ploidy vari...
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